Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides.
نویسندگان
چکیده
The immunomodulating action of two mushroom antitumor polysaccharides, polysaccharide-protein complex (PSPC) and lentinan, was elucidated through analysing the expression profile of cytokines during a time course (0 h to 48 h) after their administration. Among the 5 cytokine genes, the induction of a marked increase in the mRNA levels of IL-1alpha, IL-1beta, TNF-alpha, IFN-gamma and M-CSF by PSPC and lentinan was observed in the peritoneal exudate cells and splenocytes. However, the time point of their increased production was different after PSPC and lentinan administration.
منابع مشابه
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ورودعنوان ژورنال:
- Life sciences
دوره 64 12 شماره
صفحات -
تاریخ انتشار 1999